Ozone nano-bubbles in aquaculture involve the use of tiny ozone bubbles, in the nanometer range, to enhance water quality. Ozone is a powerful oxidizing agent that, when delivered in nano-bubble form, maximizes its contact with water. This technology offers benefits such as effective water disinfection, improved water quality through organic matter breakdown, enhanced oxygenation, algae control, biofilm removal, and disease prevention. However, careful monitoring is crucial to avoid overdosing and potential harm to aquatic organisms, and adherence to best practices is recommended.